Pre-diabetic patients with vascular disorders are found to have particular genetic or chromosomal oddity on the preleukemic condition. This result is now clearing the relation of cancer among individuals with pre-diabetes and was gathered by a renowned French-British-Qatari group led by Professor Philippe Froguel.
Found in the official website of National Genetics is the copy of this work published on 14th July, 2013.
Among the 200 million patients of diabetes worldwide, there is one out of three of them are enduring disorders in blood vessels or in nerves. Over a year ago, 2012, a couple of researches were posted on the said site of National Genetics. The said studies presented the diagnosis of chromosomal clonal mosaic events (CMEs)(2) can be studied on elderly patients’ DNA from their saliva or blood cellular make-up. This CMEs are also capable of foreseeing the potentials of acquiring other cancers such as leukemia, according to the published studies. The occurrence of CMEs is somehow insignificant for younger patients, specifically below 50 year of age. It shows to be affective of about 2% to seniors of more than 70 years of age. It is because elderly has heightened prone to cancers, especially on the hematological aspects.
Moreover, a certain complication of diabetes which is the type 2 diabetes is an illness that increases the rate of maturation among elderly. Type 2 diabetes is therefore described to be a contributing factor to hike the chances of cancer, more especially leukemia.
Froguel and his colleagues has put years of study on type 2 diabetes where they have put attention the possible effect of type 2 diabetes on CME aberrations found in cells of the blood. The success of this research was through the use of cost-effective technology for genetic analysis established on DNA arrangement (taking up just a couple of centimeters) where almost 500 thousand DNA alterations are carried out. Every DNA then lets the thorough analysis by means of a mock dissection of the genes itself.
This technique used by the researchers, almost thousands of patients aged 50 or more were found to have CMEs present in their blood DNA, as well as in type 2 diabetic patients. It was concluded that chances of having CMEs was four times more among patients suffering from type 2 diabetes than in any other conditions. Also, researchers conformed to the relation of the patient’s age to the CMEs occurrence. Significantly, they have noted that type 2 diabetes is at a much more complicated state for patients who also have diabetic CME which may cause aberrations in the eyes, heart or kidneys. With these, identification of chromosomal aberrations under CME-types are most likely to clarify the high chances of cancer acquisitions among type 2 diabetic individuals.
The research conducted implies a ground-breaking medical discovery, particularly on cancerous conditions for diabetic patients in or out early detection stages. Having this said, gene analysis of CME by means of DNA arrangements is highly recommended, especially for type 2 diabetic individuals who are in a severe state relating to aberrations in the blood vessels.
