Is Tight Blood Sugar Controls Best for Type 2 Diabetes?

This is the result of a report that was published by the German Institute for Quality and Efficiency in Health Care (IQWIG) that was recently issued.

Is Tight Blood Sugar Controls Best for Type 2 DiabetesIs Tight Blood Sugar Controls Best for Type 2 Diabetes: Should persons with type 2 diabetes keep their blood sugar levels under strict control, resulting in their A1C levels being the same as a person who does not have type 2 diabetes?

There are known benefits to keeping the blood sugar levels under tight control, but there is also a down side known as “insulin reactions” (hypoglycemia).

A true answer to the benefit of extremely tight control is still unknown.

This is the result of a report that was published by the German Institute for Quality and Efficiency in Health Care (IQWIG) that was recently issued. This compilation report was issued at the request of the Federal Joint Committee (G-BA). IQWIG was requested to prepare the report in a rapid form, meaning no preliminary reports were published. The study involved IQWIG using a randomized controlled trial comparing two treatment strategies in patients with type 2 diabetes. The “test” group measures’ goals were to lower blood sugar levels to near normal levels. In the “control” group measures’ goals there was no attempt to keep blood sugar levels at normal levels. With these two criteria in mind, the goal was to assess the benefit or harm of the interventions for “mortality (all-cause mortality), late complications of diabetes (heart attacks, strokes, damage to the kidneys or eyes, etc.), as well as quality of life.”

IQWIG included seven studies. In those seven studies, 28,000 had participated. Four studies had already been conducted between the 1960s and the 1990s, and the remaining three were after the year 2000. The ethnic origin was specific, Japan, and in some of the studies medications were used that are no longer in use. Rosiglitazone was listed as one such drug.

IQWIG analyzed these studies and their conclusion was that there were no differences between the two groups of “relevant aspects of treatment.” There was no identifiable “advantage or disadvantages found neither for all cause mortality nor for fatal heart attacks, (fatal and non-fatal) strokes, end-stage renal disease (and its pre-stages), amputations, or pre-stages of blindness. Insufficient data were available for the outcomes of quality of life and blindness.”

There were indications that patients with type 2 diabetes did benefit from extremely normal blood sugar levels in the “non-fatal heart attack” area, and it was in this area only. As well, those with the extremely normal blood sugar levels had indications of severe insulin reactions (hypoglycemia) as well as other serious events.

Jurgen Windeler, Director of IQWIG, commented on the current report: “It is quite astonishing: individual interventions, particularly drugs, have in part been well investigated in studies; however, we know relatively little about the advantages and disadvantages of treatment strategies. If doctors are faced with the question as to what they can specifically offer to their diabetes patients, whether they should lower blood glucose levels as much as possible, and in which patients this is a promising (or less promising) approach, they still do not receive satisfactory answers.”

In conclusion, the “few studies available do not allow reliable conclusions.”

Diagnosing Diabetes and Pre-Diabetes at the Dentist

Study shows test results were effective in identifying patients who were walking around with diabetes without their knowledge and also effective in identifying those who were considered pre-diabetic.

diagnosing diabetes and pre-diabetes at the dentistDiagnosing Diabetes and Pre-Diabetes at the Dentist: One in four people in the United States have type 2 diabetes or are pre-diabetic. They do not know it.

Seeing your dentist every six months, as recommended, might one day help in an earlier diagnosis for those with undiagnosed diabetes or even pre-diabetes. Having missing teeth and deep periodontal pockets might lead to an early diagnosis of diabetes, which could lead to the prevention of some of the serious side effects of diabetes, such as stroke, heart disease, kidney and eye complications. Through early diagnosis, lifestyle changes could be implemented that could alter the course of the disease, and possibly prevent the diagnosis of diabetes at a later date if one is told that they are headed down the diabetic road.

A study was undertaken by researchers at the Columbia University College of Dental Medicine, and the results were published in the Journal of Dental Research. This study involved approximately 600 patients who visited a dental facility in Northern Manhattan. The participants were 30 years old or older (if Hispanic or non-white) and 40 years old or older (if non-Hispanic and white). None of these participants had ever been diagnosed with type 2 diabetes or pre-diabetes prior to the study. There were 530 patients with at least one risk factor reported by the patient – high cholesterol, high blood pressure (hypertension), obesity, simply overweight or a family history of diabetes. Five hundred and thirty patients received a periodontal exam and an A1C test. These patients were required to return for a fasting blood glucose test, the true test for a diagnosis of diabetes or pre-diabetes.

The test results were effective in identifying the patients who were walking around with diabetes without their knowledge and also effective in identifying those who were considered pre-diabetic.

“Periodontal disease is an early complication of diabetes,” stated Dr. Ira Lamster, Dean of the College of Dental Medicine, and senior author on the research paper results. Dr. Evanthia Lalla is an associate professor at the College of Dental Medicine and was a lead author on the paper. The study was supported by a research grant from Colgate Palmolive, and the authors of the study report no potential financial or other conflicts.

Early diagnosis is the key when it comes to diabetes. The earlier a person learns of their condition, the earlier they can make the necessary changes in their life to prevent a diagnosis of diabetes or receive treatment when they do receive a diagnosis of diabetes.

People tend to see the dentist because they want to keep their teeth, and they want to have a nice, white smile. A dentist’s office would be another place where a serious health condition, such as diabetes, could be caught in its earliest stages. No steps are in place at this time to begin this sort of testing for diabetes or pre-diabetes in a dental environment, but it would be another step in the right direction for the early diagnosis of diabetes.

Nuts Over Carbs for Diabetes

The study had 117 patients coping with type 2 diabetes, and the study showed that the group that ate two ounces of nuts daily instead of carbs improved both glycemic control and serum lipids.

Nuts Over Carbs for DiabetesNuts Over Carbs for Diabetes: A recent study shows that when those dealing with type 2 diabetes switched out some of their regular carbohydrates for a half cup of mixed nuts each day, the participants’ blood sugar levels and LDL cholesterol levels dipped slightly over three months. This is no reason to eat nuts all day long, but it’s a good enough reason to think about throwing in some nuts in place of the carbs each day.

The study was led by David J.A. Jenkins, M.D., of St. Michael’s Hospital in Toronto, Canada. He “randomly assigned subjects to one of three treatments (daily supplements) for three months: mixed nuts (75 g/day; 40 patients), half portion of nuts (38 patients), or muffins (39 patients).”

The study had 117 patients coping with type 2 diabetes, and the study showed that the group that ate two ounces of nuts daily instead of carbs improved both glycemic control and serum lipids. The results of the study were published in the Diabetes Care.

We all know that nuts are high in calories, and we also know that they contain fats that are good for us. Nuts contain unsaturated fats, monounsaturated and polyunsaturated, the so-called healthy fats. These fats are believed to lower the LDL cholesterol levels, which is the bad cholesterol that clogs the arteries. Nuts also contain fiber, vitamin E, omega-3 fatty acids, plant sterols, and L-argine.

The nuts used in this study were unsalted almonds, pecans, hazelnuts, pistachios, walnuts, cashews, macadamias and peanuts. There were three groups in the study: Muffin group, full-nut group and half-nut group. The muffin group ate a “healthy” muffin, so called because the muffin was made of whole wheat products, sweetened with apple concentrate, and had no sugar added. This combination of ingredients had similar protein content to the nuts used in the study because of the egg white and skim milk powder that was contained in the muffin.

The patients in the full-nut group had a decrease in their A1C levels (0.21 percent), but the muffin group showed no such decrease. The LDL levels in the full-nut group decreased significantly, whereas the muffin group showed no such decrease.

It is known that nuts are good for you, but so is olive oil and avocadoes. This current study did not take into account the possible benefits of olive oil and avocadoes.

So you might want to think about tossing out the muffin for breakfast and replacing it with nuts. Also work in a good dose of cardio exercise for approximately 30 minutes per day and add a little light weights three or four times a week.

In some cases, type 2 diabetes can be controlled through diet and exercise, avoiding the use of oral medications, but always follow your doctor’s instructions, even before going heavy on the nuts. This study group was a group of participants who were already on medication for their type 2 diabetes and were considered to have good control over their blood sugar levels.

New Study On Aspirin and Diabetes

A goal of a recent study in Canada was to see whether taking aspirin could prevent a first or second heart attack or stroke in those with diabetes.

New Study On Aspirin and DiabetesNew Study On Aspirin and Diabetes: A baby aspirin a day can help prevent a heart attack, according to the experts. If you are in the throes of a heart attack, it is recommended that you take a chewable aspirin. We all know there are numerous cases where the use of over-the-counter aspirin can be helpful to the extent that it can save lives.

A goal of a recent study in Canada was to see whether taking aspirin could prevent a first or second heart attack or stroke in those with diabetes.

That newly released study has given results on the use of aspirin as a preventative measure for heart disease and the recurrence of episodes in patients with diabetes. The study was carried out at the University of Alberta, Canada, by researcher Scot Simpson, an Associate Professor in the Faculty of Pharmacy and Pharmaceutical Sciences.

Simpson concluded that diabetic patients who had already suffered a cardiac or stroke condition who were taking a “low” dose of aspirin daily had “very little benefit” in terms of preventing a second heart attack or a decreased risk of mortality. But, the patients taking “higher” doses of aspirin showed a significantly lower risk.

The researchers took the results from 21 different studies and zeroed in on diabetic patients who had already had a heart attack or stroke to see how aspirin could prevent a second episode. The results were that when taking 325 milligrams of aspirin per day there was a 23 percent lower risk of death.

Simpson stated that people with diabetes have an increased risk of cardiovascular disease, “adding there is evidence that suggest as much as 60 percent of deaths in diabetics is attributable to heart disease.” Simpson stated that “pharmacists could have an active role” in helping patients with their questions regarding aspirin.

Before making any changes in your medication, always check with your doctor first, especially when it comes to any over-the-counter medication. People with type 2 diabetes, in many cases, take several different medications. The addition of aspirin, without their doctor’s consent, might lead to unnecessary problems and hospitalizations.

Aspirin (acetylsalicylic acid) has been around for many, many years and is most commonly used as an analgesic to relieve minor aches and pains, to reduce fever and is an anti-inflammatory medication.

There are side effects from taking aspirin. These include, but are not limited to, stomach upset, bleeding in the stomach (ulcers), and tinnitus (ringing in the ears), especially at higher doses.

As well, aspirin is no longer recommended for use in children when they are suffering from a cold, the flu or chickenpox or other viral sicknesses because of the risk of Reye’s syndrome.

Take care to always check with your physician before adding aspirin to your medicine routine or increasing the dosage, if you are already taking aspirin. The side effects can be serious and life threatening. Your physician will know your medical history and will be able to advise you on whether or not you should add aspirin on a daily basis and whether or not you should increase the dosage.

Linagliptin (Tradjenta) Possible Approval for Use in Europe for Type 2 Treatment

Tradjenta has proven to be effective for those with type 2 diabetes who had difficulties tolerating metformin or those with kidney problems.

Linagliptin (Tradjenta) Possible Approval for Use in Europe for Type 2 TreatmentLinagliptin (Tradjenta) Possible Approval for Use in Europe for Type 2 Treatment: Linagliptin (sold under the name Tradjenta) has been available in the United States for those with type 2 diabetes since May 2011, when the Food and Drug Administration gave their approval for its use at that time. Tradjenta is an oral medication and comes in 5 mg tablets.

Tradjenta has proven to be effective for those with type 2 diabetes who had difficulties tolerating metformin or those with kidney problems. Tradjenta is used along with diet and exercise to lower blood sugar levels.

Tradjenta is not approved for use in conjunction with insulin or for the use in children. Tradjenta can cause low blood sugar levels, resulting in insulin reactions.

In June 2011, Boehringer Ingelheim and Eli Lilly and Company, the makers of linagliptin, received a positive response from the European Medicines Agency’s (EMA) Medicinal Committee recommending that linagliptin in the 5 mg dose, film-coated tablets, be approved for use in Europe. “The Committee for Medicinal Products for Human Use (CHMP) has recommended the approval of linagliptin as a monotherapy in patients inadequately controlled by diet and exercise alone and for whom metformin is inappropriate due to intolerance, or contraindicated due to renal impairment.” They are also recommending that linagliptin might be used in combination with metformin and metformin plus sulfonylurea. Their research showed that when linagliptin was used in conjunction with metformin, it reduced the A1C levels by 0.6 to 0.7 percent when compared to the use of a placebo. The positive opinion for the use in Europe of linagliptin was based on a clinical trial program that involved approximately 4,000 adults with type 2 diabetes.

Professor Anthony Barnett, Clinical Director, Department of Diabetes and Endocrinology, University of Birmingham and Heart of England NHS, UK, was quoted as saying, “This will be an important step forward in the management of type 2 diabetes in Europe.” Furthermore, he stated, “Of note, linagliptin is primarily excreted via the bile and gut, meaning no dose adjustment is recommended in patients with kidney or liver impairment. Therefore, this will be the first DPP-4 inhibitor available at one dose for all adult patients with type 2 diabetes.”

Type 2 diabetes has increasingly been diagnosed around the world. Linagliptin will be a new treatment available in the UK for those suffering from type 2 diabetes and are having difficulties controlling their blood sugar levels.

Boehringer Ingelheim and Eli Lilly and Company are part of a worldwide alliance that was formed in January 2011. Enrique Conterno, President of Lilly Diabetes was quoted as saying, “We are extremely pleased by the CHMP positive recommendation for approval of linagliptin in Europe. Based on our comprehensive studies and the CHMP’s positive recommendation, we believe linagliptin can be an important new treatment option for adult patients with type 2 diabetes.”

Apple Peels, Diabetes and Muscle Wasting

In a recent study in which mice were used, apple peel was shown to lower blood sugar levels, cholesterol and triglycerides.

Apple Peels, Diabetes and Muscle WastingApple Peels, Diabetes and Muscle Wasting: You might not want to peel that apple before eating it, let alone put an apple peel down the garbage disposal or in the trash container under the sink.

Apple peels contains a good dose of ursolic acid. Ursolic acid is a natural compound found in apple peels called pentcyclic triterpenoid and helps to burn fat and build muscle. In a recent study in which mice were used, apple peel was shown to lower blood sugar levels, cholesterol and triglycerides. Ursolic acid is also known as malol, prunol, urson, 3-B-hydroxy-urs-12-en-28-oic acid.

This study was conducted by Dr. Chris Adams, an endocrinologist and senior author of the study for the University of Iowa. The study showed that the ursolic acid found in apple peels could be helpful with the wasting away of muscles that occurs in certain diseases, and also possibly help with metabolic disorders like diabetes. The study results were published in the June 2011 issue of Cell Metabolism.

From the information from his study, Dr. Adams stated, “We found that it actually promoted the growth of muscle, so the mice got bigger muscles and actually got stronger. We can measure mouse strength with a little machine called a grip strength meter.” He added, “It didn’t have any harmful effect on the kidneys or liver or anything like that which makes sense because it’s a natural compound that we actually eat.”

The mice that received the ursolic acid became leaner and had lower blood sugar levels, cholesterol and triglycerides. Further testing will be needed before it is determined that the same positive results will prove to be true for humans.

The muscle-building aspect of the ursolic acid would be beneficial in the treatment of the infirmed and elderly.

Also, it is not known whether the amount of ursolic acid that is consumed on a daily basis by humans would produce the same results.

Ursolic acid is found in apple peels, but it is also found in other plants, including bilberries, cranberries, hawthorn, prunes, elder flowers, lavender, oregano, thyme and peppermint. Ursolic acid has already been recognized as an inhibitor of various types of cancer cells.

Ursolic acid is currently used by the cosmetic industry in the manufacture of cosmetics in its topical form due to its anti-tumor (skin cancer) properties.

Type 1 and Type 2 diabetes diagnoses are growing in number each year. Every little piece of new information garnered that could help in the treatment of these conditions helps all those with these numerous conditions.

In the meantime, we might want to do what we are always told: Eat your fruits and veggies.

Zebrafish, Zinc and Diabetes

New study shows a view of the pancreas in the fish that might help further understand the role of zinc in the development of Type 2 diabetes and various other diseases.

Zebrafish, Zinc and DiabetesZebrafish, Zinc and Diabetes: Zinc is an important trace mineral that people need to stay healthy. Only iron is in stronger form in the body than zinc. Zinc’s highest concentrations are found in the prostate gland and sperm of men, the red and white blood cells, the retinas of the eyes, the liver and the kidneys. In fact, “zinc is found throughout the body and is involved in metabolic pathways that affect the function of the immune system, the brain, reproduction and sexual development.”

In an effort to better understand zinc and its effects, a study was undertaken in England that used zebrafish to try to further the understanding of diseases like type 2 diabetes, prostate cancer and Alzhiemer’s Disease. Scientists from Queen Mary, University of London, have discovered a new way of detecting zinc in zebrafish.

This new study, run by Professor Mike Watkinson, Dr. Stephen Goldup and Dr. Caroline Brennan, all from the Queen Mary’s School of Biological and Chemical Sciences, the results of which were announced July 3, 2011, at the Sixth International Symposium on Macrocyclic and Supramolecular Chemistry, in Brighton, England, focused its efforts on the development of a sensor for zinc to be used in studies on the zebrafish.

The zebrafish is something you might see in home aquariums. It’s a pretty fish. The zebrafish (danio rerio) is a tropical freshwater fish that belongs to the minnow family. You can find this fish at your local pet store where it’s sold as “zebra danio.” The zebrafish is also very important in scientific research.

Zebrafish grow very quickly, and the babies can be grown outside the mother’s body. The embryos of zebrafish are transparent. This transparency allows the scientists to have a clear view of their organs.

The scientists in this study were able to develop a senor that could detect the zinc in the fish by switching fluorescence on the fish when zinc was present.

This allowed the scientists to view the zinc inside various parts of the zebrafish, including the pancreas, where the Islets of Langerhans (producers of insulin) are located. This new view of the pancreas in the fish might help further understand the role of zinc in the development of Type 2 diabetes and various other diseases.

Type 2 diabetes (formerly known as non-insulin dependent diabetes mellitus or adult-onset diabetes) is a metabolic disorder that results in high blood levels in the context of insulin resistance and relative insulin deficiency. Type 2 diabetes is often managed by increasing exercise and diet modification. In some cases when exercise and diet do not bring the blood sugar levels under control, oral medication may be used to treat the condition. The cause of Type 2 diabetes has long been thought to be a combination of lifestyle and genetic factors.

Today, more and more children and adolescents are being diagnosed with Type 2 diabetes, and this rise in the numbers of Type 2 diabetes-diagnosed children has been attributed in many cases to lack of exercise and the excessive intake of food. As well, environmental toxins may have contributed to this increased rate of Type 2 diabetes.

The easily viewed zinc in the zebrafish will help in discovering more and more about various diseases.

Study Shows Life Expectancy Longer Now For Type 1 Diabetics

Because of better understanding of Type 1 diabetes, and better treatment of type 1 diabetes, there has been an increase in the life expectancy for someone now diagnosed with Type 1 diabetes.

Study Shows Life Expectancy Longer Now For Type 1 DiabeticsStudy Shows Life Expectancy Longer Now For Type 1 Diabetics: Insulin was discovered in the 1920s. Prior to that time, when a person was diagnosed with Type 1 diabetes (formerly known as juvenile diabetes mellitus) that person might not live for very long, sometimes as long as only one year.

With the advent of insulin in the treatment of Type 1 diabetes (when the pancreas stops making insulin and only replacement of this insulin by artificial insulin can be done), the life expectancy of someone diagnosed with Type 1 diabetes was extended.

Because of better understanding of Type 1 diabetes, and better treatment of type 1 diabetes (better control of blood sugar levels), there has been an increase in the life expectancy for someone now diagnosed with Type 1 diabetes.

A 30-year, long-term prospective study, according to a University of Pittsburgh Graduate School of Public Healthy study that was presented at the 71st Scientific Sessions of the American Diabetes Association in San Diego, California, in June of 2011, with lead author of the study Trevor J. Orchard, M.D., and Professor of Epidemiology, Pediatrics and Medicine at the University of Pittsburgh: “The results, found in Abstract Number 0078-OR, are based on participants in the Pittsburgh Epidemiology of Diabetes Complications (EDC) study, a long-term prospective study of childhood onset Type 1 diabetes.”

The study began in 1986. The average age of the participants was 28 when they began the study and age 44 at the study’s completion. These individuals were diagnosed with Type 1 diabetes between 1950 and 1980. There has been a lack of information, studies, that addressed the life expectancy of those with Type 1 diabetes.

These study results indicated that the 30-year mortality of the participants in the study with Type 1 diabetes from 1965 to 1980 was 11.6 percent, which was a decline from the 35.6 percent 30-year mortality of those diagnosed between 1950 and 1964.

The study indicated that the life expectancy for participants diagnosed with Type 1 diabetes between 1965 and 1980 was 68.8 years, which was a 15-year improvement when compared to those diagnosed between 1950 and 1964.

Other authors of this study were Rachel G. Miller, M.S., Aaron M. Secrest, Ph.D., Ravi K. Sharma, Ph.D., and Thomas J. Songer, Ph.D., all of the University of Pittsburgh.

This study was funded by the National Institutes of Health.

New Study On Clogged Carotid Arteries And Type 1 Diabetes

Research data from a new study indicated that of 162 people (diabetic patients) between the ages of 17 and 23 had both thicker and stiffer carotids than a control group.

New Study On Clogged Carotid Arteries And Type 1 DiabetesNew Study On Clogged Carotid Arteries And Type 1 Diabetes: Atherosclerosis of the carotid arteries is a buildup of plaque in either the right or left carotid artery, located at the sides on the neck going up to the head. These carotid arteries supply oxygenated blood to the head and neck and are vital for survival. When either of these arteries becomes clogged with plaque, this blood flow to the head and neck can be stopped, and a stroke or a mini-stroke occurs, which could impact a person’s life forever. Usually, the buildup of plaque in the carotid arteries occurs over a period of time.

Research data from a study that is part of THE SEARCH CVD study, which is a collaborative effort between Colorado School of Public Health and the Cincinnati Children’s Hospital Medical Center, indicated that their study of 162 people between the ages of 17 and 23 (78 percent with Type 1 diabetes and the remainder were the control group) reflected that these diabetic patients had both thicker and stiffer carotids than the control group. These results adjusted for age, race, sex and lipids. The volunteers in the research program were adolescents and young adults with Type 1 diabetes.

Type 1 diabetes is when the pancreas no longer produces insulin and can only be treated with artificial insulin. For some unknown reason, the Islets of Langerhans within the pancreas simply stop producing insulin or doesn’t produce enough. The only treatment for Type 1 diabetes is insulin.

This new information is another incentive for tight control of the blood sugar levels, not an easy thing to do, but very important. Blood sugar levels are affected by ingested food, exercise and the injection of insulin. This is a balancing act that takes dedication and hard work.

Elaine Urbina, M.D., a cardiologist at Cincinnati Children’s Hospital Medical Center, presented the research at the meeting of the American Diabetes Association in San Diego, California, in June of 2011. Urbina was loosely quoted as stating that there are “news tools for the early detection of cardiac and artery problems in young people with Type 1 diabetes.” With this new information that was garnered from the research, new therapies can be put in place to improve those blood sugar levels, thereby reducing the cardiovascular risk factors. As a result, there could be an improvement in the cardiovascular outcome for people with Type 1 diabetes.

It has long been known that Type 1 diabetes, formerly referred to as juvenile diabetes mellitus, usually strikes when people are of a younger age. With early monitoring of cholesterol levels (a known cause of the buildup of plaque in the arteries), and treatment when these elevated levels are detected, there could be a better outcome for some with Type 1 diabetes in regards to the heart and carotid arteries. As well, buildup of plaque in the arteries is easily detected by the use of an ultrasound run over the arteries to detect any buildup that might be occurring.

These new findings from the research may lead to closer monitoring in the younger people at a younger age for artery plaque buildup.

New Drug Delivery Mechanism For Retinopathy

A pin-sized device implanted behind the eye to treat diabetic retinopathy has been developed by a team of engineers and scientists from the University of British Columbia that could be told to release drugs to treat the damage.

New Drug Delivery Mechanism For RetinopathyNew Drug Delivery Mechanism For Retinopathy: A pin-sized device implanted behind the eye to treat diabetic retinopathy has been developed by a team of engineers and scientists from the University of British Columbia that could be told to release drugs to treat the damage.

This is a new drug delivery mechanism, and the information about the mechanism was published in Lab on a Chip. Lab on a Chip is a multidisciplinary journal on innovative microfluidic and nanofluidic technologies.

The study was conducted by scientists and engineers at the University of British Columbia. The lead authors are Fatemeh Nazly Pirmoradi, a recent Ph.D. Mechanical Engineering Graduate, who completed the study for her doctoral thesis; and Mechanical Engineering Associate Professor Mu Chiao, who studies nanoscience and microelectromechanical systems for biological applications. The co-authors are Professor Helen Burt and research scientist John Jackson of the Faculty of Pharmaceutical Sciences.

Currently, diabetic retinopathy (the damage of blood vessels in the eye) is treated through laser treatment and anti-cancer drugs.

With laser treatment, some peripheral vision can be lost, as well as some loss of night vision, with each new laser procedure that is done on the afflicted eye.

With anti-cancer drugs, the problem that has been encountered is that the drugs quickly clear from the bloodstream so high doses are required, and these higher doses expose other tissues to toxicity.

One of the important things about this new research is that the delivery system would be through an external magnetic field. The research showed that by sealing the reservoir of the implanted device with an elastic magnetic polydimethylisiloxane (silicone) membrane, a specific amount of the drug could be discharged, just like squeezing a little pump.

In a series of lab tests, the University of British Columbia researchers and engineers inserted the pin-sized device with the drug docetaxel (trade name Taxotere, which is an anti-mitotic chemotherapy that is mainly used for the treatment of breast, ovarian and non-small cell lung cancer at this time). After 35 days, the device had kept its integrity with negligible leakage.

It will be several years before the University of British Columbia’s device is ready for use in patients.

Diabetic retinopathy is a leading cause of blindness in American adults. It causes changes in the blood vessels of the retina. These changes in the blood vessels cause them to swell and leak fluid. As well, there can be abnormal new blood vessels that grow on the surface of the retina. The retina of the eye is the light-sensitive tissue at the back of the eye. You have to have a healthy retina in order to have good vision. It is very important to have your eyes checked by a specialist on a regular basis so that any internal change in your retina can be detected by your doctor.

There are various stages of diabetic retinopathy:

  1. Mild nonproliferative, which is small areas of balloon-like swelling in the retina’s tiny blood vessels.
  2. As the retinopathy goes unchecked, some blood vessels that nourish the retina are blocked.
  3. A lot more blood vessels in the retina are blocked, stopping several areas of the retina from their blood supply. At this stage, the retina sends signals to the body to grow new blood vessels for nourishment.
  4. Advanced stage of retinopathy: Many more blood vessels are blocked, depriving several areas of the retina with their blood supply. These areas of the retina send signals to the body to grow new blood vessels for nourishment. This is called “proliferative retinopathy.” The new blood vessels that are grown are abnormal and fragile. They grow along the retina and along the surface of the clear, vitreous gel that fills the inside of the eye. These new blood vessels do not cause symptoms or vision loss. But, these new blood vessels are thin and have fragile walls. When leakage of blood occurs, severe vision loss and blindness can occur.

Any new treatment that is being worked on by researchers and engineers in the treatment of diabetic retinopathy is a step forward in preventing blindness in diabetic patients. In the meantime, have your eyes checked regularly.